Furthermore, with the decreased use of minimally invasive approaches and increased use of abdominal procedures, the incidence of major and minor surgical complications related to hysterectomy significantly increased after the 2014 FDA warning 8 i pledge accutane Three trials investigated the role of clodronate in the adjuvant setting by randomizing patients to placebo or oral clodronate at 1, 600 mg daily for 2 or 3 years